Antidepressant Augmentation Using theN-Methyl-d-Aspartate Antagonist Memantine
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چکیده
منابع مشابه
N - methyl - D - aspartate glutamate memantine C 57 BL / 6
알코올 의존은 평생 유병율 도 높은 편이고 적절한 치 [6] , 료 후에도 많은 환자가 재발을 경험하게 되는 단주 유지가 쉽지 않은 질환이다 따라서 알코올 의존의 치료 중에서 [9]. 재발예방을 위한 연구가 중요하며 알코올 의존의 재발 예방 , 에 대한 치료는 크게 심리 사회학적 치료와 생물학적 치료로 구분된다. 한편 실험동물에서 대뇌의 어떤 특정 부위에 자극을 가할 , 경우 이러한 자극을 더 원하게 된다는 와 의 Olds Milner [10] 결과로부터 대뇌 보상 경로가 있다는 것이 밝혀진 후 복측피 , 개지역 에서 측좌핵 (ventral tegmental area; VTA) (nucleus ac으로 가는 성 경로가 대뇌 보상 경로 cumbens; NA) dopamine 중 가장 중요한 경로로 알려져...
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N-methyl-D-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous CNS disorders ranging from acute neurodegeneration (e.g. stroke and trauma), chronic neurodegeneration (e.g. Parkinson's disease, Alzheimer's disease, Huntington's disease, ALS) to symptomatic treatment (e.g. epilepsy, Parkinson's disease, drug dependence, depression, anxiety and chronic pain). However, many...
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BACKGROUND Glutamate N-methyl-D-aspartate (NMDA) receptor antagonists exert fast-acting antidepressant effects, providing a promising way to develop a new classification of antidepressant that targets the glutamatergic system. In the present study, we examined the potential antidepressant action of 7-chlorokynurenic acid (7-CTKA), a glycine recognition site NMDA receptor antagonist, in a series...
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We examined the effect of 1-amino-3,5-dimethyladamantane (memantine) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) on the inhibition of [(3)H]MK-801 binding to crude synaptic membranes of rat forebrains in the absence or presence of Ca(2+). Ca(2+) decreased the potency of memantine to inhibit [(3)H]MK-801 binding. The effect of Ca(2+) was apparently competitive w...
متن کاملIndistinguishable synaptic pharmacodynamics of the N-methyl-D-aspartate receptor channel blockers memantine and ketamine.
Memantine and ketamine, voltage- and activation-dependent channel blockers of N-methyl-d-aspartate (NMDA) receptors (NMDARs), have enjoyed a recent resurgence in clinical interest. Steady-state pharmacodynamic differences between these blockers have been reported, but it is unclear whether the compounds differentially affect dynamic physiologic signaling. In this study, we explored nonequilibri...
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ژورنال
عنوان ژورنال: The Journal of Clinical Psychiatry
سال: 2013
ISSN: 0160-6689
DOI: 10.4088/jcp.12m08252